ZFYVE1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HBF4 |
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Clone Names | 101109065 |
Gene ID | 53349 |
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Other Names | Zinc finger FYVE domain-containing protein 1, Double FYVE-containing protein 1, SR3, Tandem FYVE fingers-1, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ZFYVE1 |
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Synonyms | DFCP1, KIAA1589, TAFF1, ZNFN2A1 |
Function | Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). |
Cellular Location | Golgi apparatus, Golgi stack. Golgi apparatus. Endoplasmic reticulum. Lipid droplet Preautophagosomal structure Mitochondrion. Note=Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386) During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663) Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). |
Tissue Location | [Isoform 2]: Highly expressed in heart. Also detected in the testis. |
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Background
The FYVE domain mediates the recruitment of proteinsinvolved in membrane trafficking and cell signaling tophosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes.This gene encodes a protein which contains two zinc-binding FYVEdomains in tandem. This protein displays a predominantly Golgi,endoplasmic reticulum and vesicular distribution. Alternativelyspliced transcript variants have been found for this gene, and theyencode two isoforms with different sizes.
References
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Heilig, R., et al. Nature 421(6923):601-607(2003)Krugmann, S., et al. Mol. Cell 9(1):95-108(2002)Ridley, S.H., et al. J. Cell. Sci. 114 (PT 22), 3991-4000 (2001) :Cheung, P.C., et al. Biochem. J. 355 (PT 1), 113-121 (2001) :
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