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Sestrin-3 Antibody (Center Y335) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P58005
Clone Names 80902006
Additional Information
Gene ID 143686
Other Names Sestrin-3, SESN3, SEST3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SESN3 (HGNC:23060)
Function May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Cellular Location Cytoplasm.
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

Sestrins form a small family of redox enzymes which regulate accumulation of Reactive Oxygen Species. They protect cells and their DNA against oxidative damage and regulate cell growth and viability. These genes are often deregulated in cancers and their inactivation accelerates the growth of model tumors in mice.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chen, C.C., et al. Dev. Cell 18(4):592-604(2010)Peeters, H., et al. Hum. Genet. 112 (5-6), 573-580 (2003) :

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$ 277.78
Cat# BP12471c
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