PION Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | A4D1B5 |
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Clone Names | 91218220 |
Gene ID | 54103 |
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Other Names | Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GSAP |
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Synonyms | PION |
Function | Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma- cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. |
Cellular Location | Golgi apparatus, trans-Golgi network |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Accumulation of neurotoxic amyloid-beta is a majorhallmark of Alzheimer disease (AD; MIM 104300). Formation ofamyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM104311), a protease with numerous substrates. PION, or GSAP,selectively increases amyloid-beta production through a mechanisminvolving its interaction with both gamma-secretase and itssubstrate, the amyloid-beta precursor protein (APP; MIM 104760)C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed20811458]).
References
He, G., et al. Nature 467(7311):95-98(2010)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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