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DNAJB6 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O75190
Clone Names 100318099
Additional Information
Gene ID 10049
Other Names DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNAJB6
Synonyms HSJ2, MRJ, MSJ1
Function Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co- chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine- containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048).
Cellular Location Cytoplasm, perinuclear region. Nucleus Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus
Research Areas
Citations (0)
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Background

This gene encodes a member of the DNAJ protein family.DNAJ family members are characterized by a highly conserved aminoacid stretch called the 'J-domain' and function as one of the twomajor classes of molecular chaperones involved in a wide range ofcellular events, such as protein folding and oligomeric proteincomplex assembly. This family member may also play a role inpolyglutamine aggregation in specific neurons. Alternative splicingof this gene results in multiple transcript variants; however, notall variants have been fully described.

References

Mitra, A., et al. J. Biol. Chem. 285(32):24686-24694(2010)Edo De Bock, C., et al. Int. J. Oncol. 36(5):1155-1163(2010)Hageman, J., et al. Mol. Cell 37(3):355-369(2010)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Dey, S., et al. Mol. Cell. Biochem. 322 (1-2), 137-142 (2009) :

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$ 277.78
Cat# BP12493c
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