DNAJB6 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75190 |
---|---|
Clone Names | 100318099 |
Gene ID | 10049 |
---|---|
Other Names | DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNAJB6 |
---|---|
Synonyms | HSJ2, MRJ, MSJ1 |
Function | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co- chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine- containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). |
Cellular Location | Cytoplasm, perinuclear region. Nucleus Cytoplasm, myofibril, sarcomere, Z line |
Tissue Location | Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the DNAJ protein family.DNAJ family members are characterized by a highly conserved aminoacid stretch called the 'J-domain' and function as one of the twomajor classes of molecular chaperones involved in a wide range ofcellular events, such as protein folding and oligomeric proteincomplex assembly. This family member may also play a role inpolyglutamine aggregation in specific neurons. Alternative splicingof this gene results in multiple transcript variants; however, notall variants have been fully described.
References
Mitra, A., et al. J. Biol. Chem. 285(32):24686-24694(2010)Edo De Bock, C., et al. Int. J. Oncol. 36(5):1155-1163(2010)Hageman, J., et al. Mol. Cell 37(3):355-369(2010)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Dey, S., et al. Mol. Cell. Biochem. 322 (1-2), 137-142 (2009) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.