ZMIZ2 (PIASz1) Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NF64 |
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Clone Names | 2013003 |
Gene ID | 83637 |
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Other Names | Zinc finger MIZ domain-containing protein 2, PIAS-like protein Zimp7, ZMIZ2, KIAA1886, ZIMP7 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1251a was selected from the N-term region of human PIASz. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ZMIZ2 |
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Synonyms | KIAA1886, ZIMP7 |
Function | Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. |
Cellular Location | Nucleus. Note=Detected at replication foci throughout S phase |
Tissue Location | Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
PIASz is a members of the PIAS (protein inhibitor of activated signal transducer and activator of transcription) family of proteins, negative regulators of the Janus family of tyrosine kinase (JAK)-signal transducer and activator of transcription pathway. PIAS proteins have been shown to act as transcriptional co-regulators of multiple signaling pathways in various cellular processes. PIASz increases ligand-dependent transcriptional activity of androgen receptor and other nuclear hormone receptors, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes.
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