CAPN6 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y6Q1 |
---|---|
Clone Names | 81006018 |
Gene ID | 827 |
---|---|
Other Names | Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM, CAPN6, CALPM, CANPX |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CAPN6 |
---|---|
Synonyms | CALPM, CANPX |
Function | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). |
Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle |
Tissue Location | Expressed only in placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Calpains are ubiquitous, well-conserved family ofcalcium-dependent, cysteine proteases. The calpain proteins areheterodimers consisting of an invariant small subunit and variablelarge subunits. The large subunit possesses a cysteine proteasedomain, and both subunits possess calcium-binding domains. Calpainshave been implicated in neurodegenerative processes, as theiractivation can be triggered by calcium influx and oxidative stress.The protein encoded by this gene is highly expressed in theplacenta. Its C-terminal region lacks any homology to thecalmodulin-like domain of other calpains. The protein lackscritical active site residues and thus is suggested to beproteolytically inactive. The protein may play a role in tumorformation by inhibiting apoptosis and promoting angiogenesis.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Secolin, R., et al. Psychiatr. Genet. 20(3):126-129(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rho, S.B., et al. Cancer Lett. 271(2):306-313(2008)Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.