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CEL Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P19835 |
|---|---|
| Clone Names | 100311182 |
| Other Names | Bile salt-activated lipase, BAL, Bile salt-stimulated lipase, BSSL, Bucelipase, Carboxyl ester lipase, Cholesterol esterase, Pancreatic lysophospholipase, Sterol esterase, CEL, BAL |
|---|---|
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CEL |
|---|---|
| Synonyms | BAL |
| Function | Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499). |
| Cellular Location | Secreted. |
| Tissue Location | Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level) (PubMed:21784842). Expressed by eosinophils. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a glycoproteinsecreted from the pancreas into the digestive tract and from thelactating mammary gland into human milk. The physiological role ofthis protein is in cholesterol and lipid-soluble vitamin esterhydrolysis and absorption. This encoded protein promotes largechylomicron production in the intestine. Also its presence inplasma suggests its interactions with cholesterol and oxidizedlipoproteins to modulate the progression of atherosclerosis. Inpancreatic tumoral cells, this encoded protein is thought to besequestrated within the Golgi compartment and is probably notsecreted. This gene contains a variable number of tandem repeat(VNTR) polymorphism in the coding region that may influence thefunction of the encoded protein.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Torsvik, J., et al. Hum. Genet. 127(1):55-64(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Li, L., et al. Metab. Clin. Exp. 57(10):1361-1368(2008)
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