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MLXIPL Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NP71
Clone Names 100318111
Additional Information
Gene ID 51085
Other Names Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLXIPL
Synonyms BHLHD14, MIO, WBSCR14
Function Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in liver, heart, kidney, cerebellum and intestinal tissues
Research Areas
Citations (0)
citation

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Background

This gene encodes a basic helix-loop-helix leucine zippertranscription factor of the Myc/Max/Mad superfamily. This proteinforms a heterodimeric complex and binds and activates, in aglucose-dependent manner, carbohydrate response element (ChoRE)motifs in the promoters of triglyceride synthesis genes. The geneis deleted in Williams-Beuren syndrome, a multisystem developmentaldisorder caused by the deletion of contiguous genes at chromosome7q11.23.

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)

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$ 277.78
Cat# BP12562b
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