|Other Names||Proto-oncogene DBL, Proto-oncogene MCF-2, MCF2-transforming protein, DBL-transforming protein, MCF2, DBL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.|
|Cellular Location||Cytoplasm. Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane|
|Tissue Location||Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis|
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Provided below are standard protocols that you may find useful for product applications.
The oncogenic protein encoded by this gene is a guaninenucleotide exchange factor (GEF) that exerts control over somemembers of the Rho family of small GTPases. Several transcriptvariants encoding different isoforms have been found for this gene.These isoforms exhibit different expression patterns and varyinglevels of GEF activity.
Piton, A., et al. Mol. Psychiatry (2010) In press :Murakami, M., et al. Int. J. Cancer 123(3):500-510(2008)Murakami, M., et al. Cancer Biol. Ther. 7(5):677-688(2008)Rojas, R.J., et al. J. Biol. Chem. 282(40):29201-29210(2007)Prag, S., et al. Mol. Biol. Cell 18(8):2935-2948(2007)
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