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PSMB10 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P40306 |
|---|---|
| Clone Names | 100311201 |
| Gene ID | 5699 |
|---|---|
| Other Names | Proteasome subunit beta type-10, Low molecular mass protein 10, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1, Proteasome MECl-1, Proteasome subunit beta-2i, PSMB10, LMP10, MECL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PSMB10 |
|---|---|
| Synonyms | LMP10, MECL1 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. |
| Cellular Location | Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the proteasome B-type family, also known as the T1Bfamily, that is a 20S core beta subunit. Proteolytic processing isrequired to generate a mature subunit. Expression of this gene isinduced by gamma interferon, and this gene product replacescatalytic subunit 2 (proteasome beta 7 subunit) in theimmunoproteasome.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Moschonas, A., et al. Mol. Cell. Biol. 28(20):6208-6222(2008)Liu, Y., et al. DNA Seq. 18(4):257-264(2007)Listovsky, T., et al. EMBO J. 23(7):1619-1626(2004)
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