HTR4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q13639 |
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Clone Names | 100311180 |
Gene ID | 3360 |
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Other Names | 5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HTR4 |
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Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli |
Tissue Location | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the family of serotoninreceptors, which are G protein coupled receptors that stimulatecAMP production in response to serotonin (5-hydroxytryptamine). Thegene product is a glycosylated transmembrane protein that functionsin both the peripheral and central nervous system to modulate therelease of various neurotransmitters. Multiple transcript variantsencoding proteins with distinct C-terminal sequences have beendescribed.
References
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)Maillet, M., et al. Biochem. J. 387 (PT 2), 463-471 (2005) :Brattelid, T., et al. Naunyn Schmiedebergs Arch. Pharmacol. 369(6):616-628(2004)Hiroi, T., et al. Biochem. Biophys. Res. Commun. 289(2):337-344(2001)Bender, E., et al. J. Neurochem. 74(2):478-489(2000)
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