|Other Names||Argininosuccinate synthase, Citrulline--aspartate ligase, ASS1, ASS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Expressed in adult liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the penultimatestep of the arginine biosynthetic pathway. There are approximately10 to 14 copies of this gene including the pseudogenes scatteredacross the human genome, among which the one located on chromosome9 appears to be the only functional gene for argininosuccinatesynthetase. Mutations in the chromosome 9 copy of ASS causecitrullinemia. Two transcript variants encoding the same proteinhave been found for this gene.
Hozyasz, K.K., et al. Arch. Oral Biol. 55(11):861-866(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kobayashi, E., et al. Mol. Cancer Ther. 9(3):535-544(2010)Tsai, W.B., et al. Mol. Cancer Ther. 8(12):3223-3233(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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