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SENP8 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96LD8 |
|---|---|
| Clone Names | 2100404 |
| Gene ID | 123228 |
|---|---|
| Other Names | Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, Sentrin/SUMO-specific protease SENP8, SENP8, DEN1, NEDP1, PRSC2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1260a was selected from the C-term region of human SENP8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SENP8 |
|---|---|
| Synonyms | DEN1, NEDP1, PRSC2 |
| Function | Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. |
| Tissue Location | Broadly expressed, with highest levels in kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NEDD8 is a ubiquitin-like protein that becomes conjugated to the cullin subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. SENP8 is a protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
References
Wu, K., et al., J. Biol. Chem. 278(31):28882-28891 (2003).Gan-Erdene, T., et al., J. Biol. Chem. 278(31):28892-28900 (2003).Mendoza, H.M., et al., J. Biol. Chem. 278(28):25637-25643 (2003).
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