SQLE Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14534 |
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Clone Names | 100324049 |
Gene ID | 6713 |
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Other Names | Squalene monooxygenase, Squalene epoxidase, SE, SQLE, ERG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SQLE |
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Synonyms | ERG1 |
Function | Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. |
Cellular Location | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein |
Tissue Location | Detected in liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Squalene epoxidase catalyzes the first oxygenation step insterol biosynthesis and is thought to be one of the rate-limitingenzymes in this pathway.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Helms, M.W., et al. Br. J. Cancer 99(5):774-780(2008)Liu, Y., et al. Lung Cancer 56(3):307-317(2007)
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