|Other Names||Claudin-2, SP82, CLDN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the claudin protein familywhose members have been identified as major integral membraneproteins localized exclusively at tight junctions. Claudins areexpressed in an organ-specific manner and regulate tissue-specificphysiologic properties of tight junctions. This protein isexpressed in the intestine. Alternatively spliced transcriptvariants with different 5' untranslated region have been found forthis gene.
Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55(3):306-315(2010)Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010)Szakal, D.N., et al. Virchows Arch. 456(3):245-250(2010)Buchert, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2628-2633(2010)Mankertz, J., et al. Cell Tissue Res. 336(1):67-77(2009)
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