|Other Names||Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, Mint-2, APBA2, MINT2, X11L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.|
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The protein encoded by this gene is a member of the X11protein family. It is a neuronal adapter protein that interactswith the Alzheimer's disease amyloid precursor protein (APP). Itstabilizes APP and inhibits production of proteolytic APP fragmentsincluding the A beta peptide that is deposited in the brains ofAlzheimer's disease patients. This gene product is believed to beinvolved in signal transduction processes. It is also regarded as aputative vesicular trafficking protein in the brain that can form acomplex with the potential to couple synaptic vesicle exocytosis toneuronal cell adhesion. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009)Mitchell, J.C., et al. Hum. Mol. Genet. 18(23):4492-4500(2009)Babatz, T.D., et al. Autism Res 2(6):359-364(2009)Chang, S.J., et al. BMC Genomics 10, 613 (2009) :
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