STAMBP Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95630 |
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Clone Names | 100318055 |
Gene ID | 10617 |
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Other Names | STAM-binding protein, 3419-, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | STAMBP |
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Synonyms | AMSH {ECO:0000303|PubMed:10383417} |
Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). |
Cellular Location | Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine-mediated signal transduction in the JAK-STATcascade requires the involvement of adaptor molecules. One suchsignal-transducing adaptor molecule contains an SH3 domain that isrequired for induction of MYC and cell growth. The protein encodedby this gene binds to the SH3 domain of the signal-transducingadaptor molecule, and plays a critical role in cytokine-mediatedsignaling for MYC induction and cell cycle progression. Multiplealternatively spliced transcript variants encoding the same proteinisoform have been found for this gene.
References
Sierra, M.I., et al. J. Biol. Chem. 285(18):13990-14004(2010)Hasdemir, B., et al. J. Biol. Chem. 284(41):28453-28466(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Wang, P., et al. BMC Genomics 10, 518 (2009) :Sato, Y., et al. Nature 455(7211):358-362(2008)
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