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CNGB3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NQW8 |
|---|---|
| Clone Names | 100318256 |
| Gene ID | 54714 |
|---|---|
| Other Names | Cyclic nucleotide-gated cation channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-3, CNG channel beta-3, CNGB3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CNGB3 |
|---|---|
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed specifically in the retina. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the beta subunit of a cyclicnucleotide-gated ion channel. The encoded beta subunit appears toplay a role in modulation of channel function in conephotoreceptors. This heterotetrameric channel is necessary forsensory transduction, and mutations in this gene have beenassociated with achromatopsia 3, progressive cone dystrophy, andjuvenile macular degeneration, also known as Stargardt Disease.
References
Komaromy, A.M., et al. Hum. Mol. Genet. 19(13):2581-2593(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thiadens, A.A., et al. Ophthalmology 117(4):825-830(2010)Azam, M., et al. Mol. Vis. 16, 774-781 (2010) :Peng, C., et al. J. Biol. Chem. 278(36):34533-34540(2003)
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