SLC23A1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UHI7 |
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Clone Names | 100311249 |
Gene ID | 9963 |
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Other Names | Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, hSVCT1, Yolk sac permease-like molecule 3, SLC23A1, SVCT1, YSPL3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC23A1 (HGNC:10974) |
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Function | Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The absorption of vitamin C into the body and itsdistribution to organs requires two sodium-dependent vitamin Ctransporters. This gene encodes one of the two transporters. Theencoded protein is active in bulk vitamin C transport involvingepithelial surfaces. Previously, this gene had an official symbolof SLC23A2. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Timpson, N.J., et al. Am. J. Clin. Nutr. 92(2):375-382(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Michels, A.J., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1220-C1227 (2009) :Cahill, L.E., et al. J Nutrigenet Nutrigenomics 2(6):292-301(2009)
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