|Other Names||Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL 1, hSPL, Sphingosine-1-phosphate aldolase, SGPL1, KIAA1252|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type III membrane protein|
|Tissue Location||Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).|
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Provided below are standard protocols that you may find useful for product applications.
SGPL1 cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
Seo, Y.J., et al. J. Virol. 84(16):8124-8131(2010)Vogel, P., et al. PLoS ONE 4 (1), E4112 (2009) :Peest, U., et al. J. Cell. Biochem. 104(3):756-772(2008)Morgan, A.R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :Oskouian, B., et al. Proc. Natl. Acad. Sci. U.S.A. 103(46):17384-17389(2006)
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