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TTF-1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15361 |
|---|---|
| Clone Names | 80722105 |
| Gene ID | 7270 |
|---|---|
| Other Names | Transcription termination factor 1, TTF-1, RNA polymerase I termination factor, Transcription termination factor I, TTF-I, TTF1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TTF1 |
|---|---|
| Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q62187}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus {ECO:0000250|UniProtKB:Q62187} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The TTF1 gene encodes a transcription termination factorthat regulates ribosomal gene transcription (summarized by Green etal., 2010 [PubMed 20448178]).
References
Montanelli, L., et al. Mol. Cell. Endocrinol. 322 (1-2), 64-71 (2010) :Lessard, F., et al. Mol. Cell 38(4):539-550(2010)Green, R.E., et al. Science 328(5979):710-722(2010)McCluggage, W.G., et al. Am. J. Surg. Pathol. 34(4):525-532(2010)Kreil, S., et al. Leuk. Res. 33 (9), E168-E169 (2009) :
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