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DDX3Y Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15523 |
|---|---|
| Clone Names | 100318232 |
| Gene ID | 8653 |
|---|---|
| Other Names | ATP-dependent RNA helicase DDX3Y, DEAD box protein 3, Y-chromosomal, DDX3Y, DBY |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DDX3Y |
|---|---|
| Function | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm in an XPO1- dependent manner |
| Tissue Location | Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level) Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (PubMed:15294876) |
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Provided below are standard protocols that you may find useful for product applications.
Background
DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. This gene encodes a DEAD box protein,and it has a homolog on the X chromosome. The gene mutation causesmale infertility, Sertoli cell-only syndrome or severehypospermatogenesis, suggesting that this gene plays a key role inthe spermatogenic process. Alternatively spliced variants, encodingthe same protein, have been identified.
References
Rosinski, K.V., et al. Blood 111(9):4817-4826(2008)Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Ficarro, S.B., et al. Rapid Commun. Mass Spectrom. 19(1):57-71(2005)
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