STARD4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96DR4 |
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Clone Names | 100416038 |
Gene ID | 134429 |
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Other Names | StAR-related lipid transfer protein 4, START domain-containing protein 4, StARD4, STARD4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | STARD4 |
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Function | Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cholesterol homeostasis is regulated, at least in part, bysterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM184756) and by liver X receptors (e.g., LXRA; MIM 602423). Uponsterol depletion, LXRs are inactive and SREBPs are cleaved, afterwhich they bind promoter SREs and activate genes involved incholesterol biosynthesis and uptake. Sterol transport is mediatedby vesicles or by soluble protein carriers, such as steroidogenicacute regulatory protein (STAR; MIM 600617). STAR is homologous toa family of proteins containing a 200- to 210-amino acidSTAR-related lipid transfer (START) domain, including STARD4(Soccio et al., 2002 [PubMed 12011452]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Korytowski, W., et al. Biochem. Biophys. Res. Commun. 392(1):58-62(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rodriguez-Agudo, D., et al. J. Lipid Res. 49(7):1409-1419(2008)
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