|Other Names||CTD nuclear envelope phosphatase 1, Serine/threonine-protein phosphatase dullard, CTDNEP1, DULLARD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein|
|Tissue Location||Muscle specific with lower expression in other metabolic tissues.|
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Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling.
Kim, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(16):6596-6601(2007)Zhang, Y., et al. Mol. Cell 24(5):759-770(2006)Satow, R., et al. Dev. Cell 11(6):763-774(2006)Satow, R., et al. Biochem. Biophys. Res. Commun. 295(1):85-91(2002)
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