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BHMT2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H2M3 |
|---|---|
| Clone Names | 100324275 |
| Gene ID | 23743 |
|---|---|
| Other Names | S-methylmethionine--homocysteine S-methyltransferase BHMT2, SMM-hcy methyltransferase, Betaine--homocysteine S-methyltransferase 2, BHMT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BHMT2 |
|---|---|
| Function | Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. |
| Tissue Location | Expressed in liver and kidney and at reduced levels in the brain, heart, and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Homocysteine is a sulfur-containing amino acid that playsa crucial role in methylation reactions. Transfer of the methylgroup from betaine to homocysteine creates methionine, whichdonates the methyl group to methylate DNA, proteins, lipids, andother intracellular metabolites. The protein encoded by this geneis one of two methyl transferases that can catalyze the transfer ofthe methyl group from betaine to homocysteine. Anomalies inhomocysteine metabolism have been implicated in disorders rangingfrom vascular disease to neural tube birth defects such as spinabifida. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
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