|Other Names||Phosphatase and actin regulator 3, Scaffold-associated PP1-inhibiting protein, Scapinin, PHACTR3, C20orf101, SCAPIN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions|
|Tissue Location||Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL- 60 leukemia cells|
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The protein encoded by this gene is associated with thenuclear scaffold in proliferating cells. It was found to bind tothe catalytic subunit of protein phosphatase-1 (PP1) and inhibitPP1 activity, suggesting that this protein may function as aregulatory subunit of PP1. Alternative splicing at this locusresults in several transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Bankovic, J., et al. Lung Cancer 67(2):151-159(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sagara, J., et al. PLoS ONE 4 (1), E4247 (2009) :
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