SLC32A1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H598 |
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Clone Names | 100405162 |
Gene ID | 140679 |
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Other Names | Vesicular inhibitory amino acid transporter, GABA and glycine transporter, Solute carrier family 32 member 1, Vesicular GABA transporter, hVIAAT, SLC32A1, VGAT, VIAAT |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC32A1 (HGNC:11018) |
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Synonyms | VGAT, VIAAT |
Function | Antiporter that exchanges vesicular protons for cytosolic 4- aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4- aminobutanoate uptake (By similarity). |
Cellular Location | Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein. Presynapse {ECO:0000250|UniProtKB:O35633}. Note=Presents in glycine-, GABA- or GABA- and glycine-containing boutons {ECO:0000250|UniProtKB:O35458} |
Tissue Location | Retina. Expressed throughout the horizontal cells or more specifically at the terminals. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an integral membraneprotein involved in gamma-aminobutyric acid (GABA) and glycineuptake into synaptic vesicles. The encoded protein is a member ofamino acid/polyamine transporter family II.
References
Juge, N., et al. J. Biol. Chem. 284(50):35073-35078(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :Hashimoto, T., et al. Mol. Psychiatry 13(2):147-161(2008)Gasnier, B. Pflugers Arch. 447(5):756-759(2004)Geigerseder, C., et al. Neuroendocrinology 77(5):314-323(2003)
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