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SEC62 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99442
Clone Names 100405201
Peptide ID 100405201
Additional Information
Gene ID 7095
Other Names Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1, SEC62, TLOC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC62
Synonyms TLOC1
Function Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel- forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.The protein encoded by this gene and SEC63 protein are found to beassociated with ribosome-free SEC61 complex. It is speculated thatSec61-Sec62-Sec63 may perform post-translational proteintranslocation into the ER. The Sec61-Sec62-Sec63 complex might alsoperform the backward transport of ER proteins that are subject tothe ubiquitin-proteasome-dependent degradation pathway. The encodedprotein is an integral membrane protein located in the rough ER.


Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)Jung, V., et al. Mol. Cancer Res. 4(3):169-176(2006)Meyer, H.A., et al. J. Biol. Chem. 275(19):14550-14557(2000)

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Cat# BP12850a
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