|Other Names||Sorting nexin-4, SNX4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.|
|Cellular Location||Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC)|
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This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein associated with the long isoform of theleptin receptor and with receptor tyrosine kinases forplatelet-derived growth factor, insulin, and epidermal growthfactor in cell cultures, but its function is unknown. This proteinmay form oligomeric complexes with family members. [provided byRefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :Skanland, S.S., et al. PLoS ONE 4 (6), E5935 (2009) :Traer, C.J., et al. Nat. Cell Biol. 9(12):1370-1380(2007)Skanland, S.S., et al. Traffic 8(3):297-309(2007)Leprince, C., et al. J. Cell. Sci. 116 (PT 10), 1937-1948 (2003) :
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