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Xenopus SUMO2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7ZTK7 |
|---|---|
| Clone Names | 3030503 |
| Gene ID | 379777 |
|---|---|
| Other Names | Small ubiquitin-related modifier 2-A, SUMO-2-A, sumo2-a, smt3h2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1285a was selected from the N-term region of human Xenopus SUMO2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | sumo2-a |
|---|---|
| Synonyms | smt3h2 |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SUMO2 is a ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. SUMO2 does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. This protein plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS isoforms 1-4.
References
Muller S, et al., Nat Rev Mol Cell Biol. 2001 2(3):202-10 Review.Hochstrasser M. Cell. 2001 107(1):5-8. Review.Kahyo T, et al., Mol Cell. 2001 Sep;8(3):713-8.Yeh ET, et al., Gene. 2000 May 2;248(1-2):1-14. Review.Keane,M.M., et al., Oncogene 18 (22), 3365-3375 (1999)
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