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PTGR2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N8N7 |
|---|---|
| Clone Names | 100405269 |
| Gene ID | 145482 |
|---|---|
| Other Names | Prostaglandin reductase 2, PRG-2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1, PTGR2, ZADH1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTGR2 (HGNC:20149) |
|---|---|
| Synonyms | ZADH1 |
| Function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme involved in the metabolism ofprostaglandins. The encoded protein catalyzes the NADPH-dependentconversion of 15-keto-prostaglandin E2 to15-keto-13,14-dihydro-prostaglandin E2. This protein may also beinvolved in regulating activation of the peroxisomeproliferator-activated receptor. Alternative splicing results inmultiple transcript variants.
References
Wu, Y.H., et al. Structure 16(11):1714-1723(2008)Gao, K., et al. Int. J. Oncol. 32(6):1343-1349(2008)Chou, W.L., et al. J. Biol. Chem. 282(25):18162-18172(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, L., et al. Cytogenet. Genome Res. 103 (1-2), 79-83 (2003) :
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