|Other Names||Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN, CPN1, ACBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Synthesized in the liver and secreted in plasma|
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Provided below are standard protocols that you may find useful for product applications.
Carboxypeptidase N is a plasma metallo-protease thatcleaves basic amino acids from the C terminal of peptides andproteins. The enzyme is important in the regulation of peptideslike kinins and anaphylatoxins, and has also been known askininase-1 and anaphylatoxin inactivator. This enzyme is a tetramercomprised of two identical regulatory subunits and two identicalcatalytic subunits; this gene encodes the catalytic subunit.Mutations in this gene can be associated with angioedema or chronicurticaria resulting from carboxypeptidase N deficiency. [providedby RefSeq].
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Du, X.Y., et al. J. Biol. Chem. 284(2):751-758(2009)Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)Skidgel, R.A., et al. Int. Immunopharmacol. 7(14):1888-1899(2007)
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