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GCDH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92947 |
|---|---|
| Clone Names | 90121134 |
| Gene ID | 2639 |
|---|---|
| Other Names | Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GCDH |
|---|---|
| Function | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Isoform Long and isoform Short are expressed in fibroblasts and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the acyl-CoAdehydrogenase family. It catalyzes the oxidative decarboxylation ofglutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathwayof L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It useselectron transfer flavoprotein as its electron acceptor. The enzymeexists in the mitochondrial matrix as a homotetramer of 45-kDsubunits. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Park, J.D., et al. J. Korean Med. Sci. 25(6):957-960(2010)Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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