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PPARA Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q07869 |
|---|---|
| Clone Names | 90625188 |
| Gene ID | 5465 |
|---|---|
| Other Names | Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPARA |
|---|---|
| Synonyms | NR1C1, PPAR |
| Function | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
| Cellular Location | Nucleus. |
| Tissue Location | Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Peroxisome proliferators include hypolipidemic drugs,herbicides, leukotriene antagonists, and plasticizers; this termarises because they induce an increase in the size and number ofperoxisomes. Peroxisomes are subcellular organelles found in plantsand animals that contain enzymes for respiration and forcholesterol and lipid metabolism. The action of peroxisomeproliferators is thought to be mediated via specific receptors,called PPARs, which belong to the steroid hormone receptorsuperfamily. PPARs affect the expression of target genes involvedin cell proliferation, cell differentiation and in immune andinflammation responses. Three closely related subtypes (alpha,beta/delta, and gamma) have been identified. This gene encodes thesubtype PPAR-alpha, which is a nuclear transcription factor.Multiple alternatively spliced transcript variants have beendescribed for this gene, although the full-length nature of onlytwo has been determined.
References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Eynon, N., et al. Mitochondrion (2010) In press :Aldhoon, B., et al. Folia Biol. (Praha) 56(3):116-123(2010)
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