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HMBS Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08397 |
|---|---|
| Clone Names | 90121163 |
| Gene ID | 3145 |
|---|---|
| Other Names | Porphobilinogen deaminase, PBG-D, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase, HMBS, PBGD, UPS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HMBS |
|---|---|
| Synonyms | PBGD, UPS |
| Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679, PubMed:18004775). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). |
| Cellular Location | Cytoplasm. |
| Tissue Location | [Isoform 1]: Is ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the hydroxymethylbilanesynthase superfamily. The encoded protein is the third enzyme ofthe heme biosynthetic pathway and catalyzes the head to tailcondensation of four porphobilinogen molecules into the linearhydroxymethylbilane. Mutations in this gene are associated with theautosomal dominant disease acute intermittent porphyria.Alternatively spliced transcript variants encoding differentisoforms have been described.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Surin, V.L., et al. Genetika 46(4):540-552(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gill, R., et al. Biochem. J. 420(1):17-25(2009)Ulbrichova, D., et al. FEBS J. 276(7):2106-2115(2009)
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