|Other Names||Glucose-induced degradation protein 8 homolog, Two hybrid-associated protein 1 with RanBPM, Twa1, GID8, C20orf11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).|
|Cellular Location||Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation.|
|Tissue Location||Up-regulated in colorectal cancer tissues (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Lamesch, P., et al. Genomics 89(3):307-315(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Umeda, M., et al. Gene 303, 47-54 (2003) :Wistow, G., et al. Mol. Vis. 8, 171-184 (2002) :Deloukas, P., et al. Nature 414(6866):865-871(2001)
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