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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P09912 |
|---|---|
| Clone Names | 100324139 |
| Peptide ID | 100324139 |
| Gene ID | 2537 |
|---|---|
| Other Names | Interferon alpha-inducible protein 6, Interferon-induced protein 6-16, Ifi-6-16, IFI6, G1P3 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFI6 (HGNC:4054) |
|---|---|
| Function | Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was first identified as one of the many genesinduced by interferon. The encoded protein may play a critical rolein the regulation of apoptosis. A minisatellite that consists of 26repeats of a 12 nucleotide repeating element resembling themammalian splice donor consensus sequence begins near the end ofthe second exon. Alternatively spliced transcript variants thatencode different isoforms by using the two downstream repeat unitsas splice donor sites have been described.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Szegedi, K., et al. Exp. Dermatol. 19(3):269-278(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Zhao, D., et al. Virol. J. 5, 114 (2008) :Cheriyath, V., et al. J. Clin. Invest. 117(10):3107-3117(2007)
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