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IFI6 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P09912 |
|---|---|
| Clone Names | 100324139 |
| Gene ID | 2537 |
|---|---|
| Other Names | Interferon alpha-inducible protein 6, Interferon-induced protein 6-16, Ifi-6-16, IFI6, G1P3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFI6 (HGNC:4054) |
|---|---|
| Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro- apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was first identified as one of the many genesinduced by interferon. The encoded protein may play a critical rolein the regulation of apoptosis. A minisatellite that consists of 26repeats of a 12 nucleotide repeating element resembling themammalian splice donor consensus sequence begins near the end ofthe second exon. Alternatively spliced transcript variants thatencode different isoforms by using the two downstream repeat unitsas splice donor sites have been described.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Szegedi, K., et al. Exp. Dermatol. 19(3):269-278(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Zhao, D., et al. Virol. J. 5, 114 (2008) :Cheriyath, V., et al. J. Clin. Invest. 117(10):3107-3117(2007)
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