|Other Names||Secreted frizzled-related protein 5, sFRP-5, Frizzled-related protein 1b, FRP-1b, Secreted apoptosis-related protein 3, SARP-3, SFRP5, FRP1B, SARP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.|
|Tissue Location||Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.|
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Secreted frizzled-related protein 5 (SFRP5) is a member ofthe SFRP family that contains a cysteine-rich domain homologous tothe putative Wnt-binding site of Frizzled proteins. SFRPs act assoluble modulators of Wnt signaling. SFRP5 and SFRP1 may beinvolved in determining the polarity of photoreceptor cells in theretina. SFRP5 is highly expressed in the retinal pigmentepithelium, and moderately expressed in the pancreas. [provided byRefSeq].
Su, H.Y., et al. Int. J. Cancer 127(3):555-567(2010)Sharma, S., et al. Am. J. Respir. Crit. Care Med. 181(4):328-336(2010)Jost, E., et al. Cancer Lett. 281(1):24-31(2009)Zhao, C., et al. BMC Cancer 9, 224 (2009) :Tanaka, J., et al. Hepatogastroenterology 55(85):1265-1268(2008)
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