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UQCRB Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14927 |
|---|---|
| Clone Names | 91102222 |
| Gene ID | 7381 |
|---|---|
| Other Names | Cytochrome b-c1 complex subunit 7, Complex III subunit 7, Complex III subunit VII, QP-C, Ubiquinol-cytochrome c reductase complex 14 kDa protein, UQCRB, UQBP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UQCRB |
|---|---|
| Synonyms | UQBP |
| Function | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00128}; Matrix side {ECO:0000250|UniProtKB:P00128} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which is part of theubiquinol-cytochrome c oxidoreductase complex which contains tennuclear-encoded and one mitochondrial-encoded subunits. The encodedprotein binds ubiquinone and participates in the transfer ofelectrons when ubiquinone is bound. Mutations in this gene areassociated with mitochondrial complex III deficiency. A pseudogenehas been described on the X chromosome.
References
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Haut, S., et al. Hum. Genet. 113(2):118-122(2003)Malaney, S., et al. Cytogenet. Cell Genet. 73(4):297-299(1996)Suzuki, H., et al. J. Biol. Chem. 265(14):8159-8163(1990)Hosokawa, Y., et al. Biochem. Int. 21(1):41-44(1990)
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