HERV-FRD Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P60508 |
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Clone Names | 100324158 |
Gene ID | 405754 |
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Other Names | Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p241 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVFRD-1, ERVFRDE1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ERVFRD-1 |
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Synonyms | ERVFRDE1 |
Function | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). |
Cellular Location | Virion. [Transmembrane protein]: Cell membrane; Single-pass membrane protein |
Tissue Location | Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human endogenous retroviruses (HERVs) make upapproximately 8% of the human genome. Although most HERVs arenonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRDenvelope (env) proteins can induce cell-cell fusion when expressedin cells possessing appropriate receptors (Blaise et al., 2003[PubMed 14557543]).
References
Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009)Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008)Malassine, A., et al. Retrovirology 5, 6 (2008) :Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007)Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007) :
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