|Other Names||Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p241 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVFRD-1, ERVFRDE1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).|
|Cellular Location||Virion. Transmembrane protein: Cell membrane; Single-pass membrane protein|
|Tissue Location||Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea|
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Provided below are standard protocols that you may find useful for product applications.
Human endogenous retroviruses (HERVs) make upapproximately 8% of the human genome. Although most HERVs arenonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRDenvelope (env) proteins can induce cell-cell fusion when expressedin cells possessing appropriate receptors (Blaise et al., 2003[PubMed 14557543]).
Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009)Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008)Malassine, A., et al. Retrovirology 5, 6 (2008) :Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007)Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007) :
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