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MBNL2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5VZF2
Clone Names 100406029
Additional Information
Gene ID 10150
Other Names Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39, MBNL2, MBLL, MBLL39, MLP1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBNL2
Synonyms MBLL, MBLL39, MLP1
Function Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
Cellular Location Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853)
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Research Areas
Citations (0)
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Background

This gene encodes a C3H-type zinc finger protein, which issimilar to the Drosophila melanogaster muscleblind B protein.Drosophila muscleblind is a gene required for photoreceptordifferentiation. Several alternatively spliced transcript variantshave been described but the full-length natures of only some havebeen determined.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :He, F., et al. Protein Sci. 18(1):80-91(2009)Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009)Paul, S., et al. EMBO J. 25(18):4271-4283(2006)Adereth, Y., et al. Nat. Cell Biol. 7(12):1240-1247(2005)

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$ 277.78
Cat# BP13023b
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