CTPS2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRF8 |
---|---|
Clone Names | 100406068 |
Gene ID | 56474 |
---|---|
Other Names | CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CTPS2 |
---|---|
Function | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the formationof CTP from UTP with the concomitant deamination of glutamine toglutamate. This protein is the rate-limiting enzyme in thesynthesis of cytosine nucleotides, which play an important role invarious metabolic processes and provide the precursors necessaryfor the synthesis of RNA and DNA. Cancer cells that exhibitincreased cell proliferation also exhibit an increased activity ofthis encoded protein. Thus, this protein is an attractive targetfor selective chemotherapy. Three alternatively spliced transcriptvariants encoding the same protein have been described for thisgene.
References
Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)Ross, M.T., et al. Nature 434(7031):325-337(2005)van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1492 (2-3), 548-552 (2000) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.