|Other Names||CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the formationof CTP from UTP with the concomitant deamination of glutamine toglutamate. This protein is the rate-limiting enzyme in thesynthesis of cytosine nucleotides, which play an important role invarious metabolic processes and provide the precursors necessaryfor the synthesis of RNA and DNA. Cancer cells that exhibitincreased cell proliferation also exhibit an increased activity ofthis encoded protein. Thus, this protein is an attractive targetfor selective chemotherapy. Three alternatively spliced transcriptvariants encoding the same protein have been described for thisgene.
Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)Ross, M.T., et al. Nature 434(7031):325-337(2005)van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1492 (2-3), 548-552 (2000) :
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