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CTPS2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NRF8
Clone Names 100406068
Additional Information
Gene ID 56474
Other Names CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTPS2
Function Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene catalyzes the formationof CTP from UTP with the concomitant deamination of glutamine toglutamate. This protein is the rate-limiting enzyme in thesynthesis of cytosine nucleotides, which play an important role invarious metabolic processes and provide the precursors necessaryfor the synthesis of RNA and DNA. Cancer cells that exhibitincreased cell proliferation also exhibit an increased activity ofthis encoded protein. Thus, this protein is an attractive targetfor selective chemotherapy. Three alternatively spliced transcriptvariants encoding the same protein have been described for thisgene.

References

Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)Ross, M.T., et al. Nature 434(7031):325-337(2005)van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1492 (2-3), 548-552 (2000) :

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$ 277.78
Cat# BP13030b
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