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LILRB5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75023 |
|---|---|
| Clone Names | 100406079 |
| Gene ID | 10990 |
|---|---|
| Other Names | Leukocyte immunoglobulin-like receptor subfamily B member 5, CD85 antigen-like family member C, Leukocyte immunoglobulin-like receptor 8, LIR-8, CD85c, LILRB5, LIR8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LILRB5 |
|---|---|
| Synonyms | LIR8 |
| Function | May act as receptor for class I MHC antigens. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Detected in a natural killer (NK) cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the leukocyte immunoglobulin-likereceptor (LIR) family, which is found in a gene cluster atchromosomal region 19q13.4. The encoded protein belongs to thesubfamily B class of LIR receptors which contain two or fourextracellular immunoglobulin domains, a transmembrane domain, andtwo to four cytoplasmic immunoreceptor tyrosine-based inhibitorymotifs (ITIMs). Several other LIR subfamily B receptors areexpressed on immune cells where they bind to MHC class I moleculeson antigen-presenting cells and inhibit stimulation of an immuneresponse. Multiple transcript variants encoding different isoformshave been found for this gene.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tedla, N., et al. J. Leukoc. Biol. 83(2):334-343(2008)Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)Borges, L., et al. J. Immunol. 159(11):5192-5196(1997)
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