NIT1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86X76 |
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Clone Names | 100406174 |
Gene ID | 4817 |
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Other Names | Nitrilase homolog 1, 35--, NIT1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NIT1 |
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Function | Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
Cellular Location | [Isoform 2]: Mitochondrion {ECO:0000250|UniProtKB:Q8VDK1} |
Tissue Location | Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the nitrilase protein familywith homology to bacterial and plant nitrilases, enzymes thatcleave nitriles and organic amides to the corresponding carboxylicacids plus ammonia. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
Semba, S., et al. J. Biol. Chem. 281(38):28244-28253(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Pekarsky, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 95(15):8744-8749(1998)
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