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KREMEN2 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NCW0
Clone Names 100406246
Peptide ID 100406246
Additional Information
Gene ID 79412
Other Names Kremen protein 2, Dickkopf receptor 2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose, KREMEN2, KRM2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KREMEN2
Synonyms KRM2
Function Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

This gene encodes a high-affinity dickkopf homolog 1(DKK1) transmembrane receptor that functionally cooperates withDKK1 to block wingless (WNT)/beta-catenin signaling. The encodedprotein forms a ternary membrane complex with DKK1 and the WNTreceptor lipoprotein receptor-related protein 6 (LRP6), and inducesrapid endocytosis and removal of LRP6 from the plasma membrane. Itcontains extracellular kringle, WSC, and CUB domains. Alternativelyspliced transcript variants encoding distinct isoforms have beenobserved for this gene.

References

Mao, B., et al. Nature 417(6889):664-667(2002)

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Cat# BP13054c
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