|Other Names||Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.|
|Cellular Location||Nucleus. Cytoplasm. Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand- binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.|
|Tissue Location||Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).|
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The androgen receptor gene is more than 90 kb long andcodes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain.The protein functions as a steroid-hormone activated transcriptionfactor. Upon binding the hormone ligand, the receptor dissociatesfrom accessory proteins, translocates into the nucleus, dimerizes,and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments thatencode polyglutamine and polyglycine tracts in the N-terminaltransactivation domain of its protein. Expansion of thepolyglutamine tract causes spinal bulbar muscular atrophy (Kennedydisease). Mutations in this gene are also associated with completeandrogen insensitivity (CAIS). Two alternatively spliced variantsencoding distinct isoforms have been described. [provided byRefSeq].
Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010)Nedelsky, N.B., et al. Neuron 67(6):936-952(2010)Panda, B., et al. Gynecol. Endocrinol. (2010) In press :Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press :Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :
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