ERLIN1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75477 |
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Clone Names | 100405025 |
Gene ID | 10613 |
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Other Names | Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1, ERLIN1, C10orf69, KE04, KEO4, SPFH1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ERLIN1 (HGNC:16947) |
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Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane |
Tissue Location | Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :Wang, Y., et al. Biochim. Biophys. Acta 1793(11):1710-1718(2009)Pearce, M.M., et al. J. Biol. Chem. 284(16):10433-10445(2009)Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
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