Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC26A7 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TE54 |
|---|---|
| Clone Names | 100405072 |
| Gene ID | 115111 |
|---|---|
| Other Names | Anion exchange transporter, Solute carrier family 26 member 7, SLC26A7 (HGNC:14467) |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC26A7 (HGNC:14467) |
|---|---|
| Function | Acts as an anion channel mediating the transport of chloride, sulfate and oxalate ions (PubMed:11834742). Mediates the transport of bromide, iodide, nitrate, gluconate, thiocyanate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:31372509). Although it is an anion channel, according to PubMed:12736153 and PubMed:32119864 it has been shown to exhibit chloride-bicarbonate exchanger activity. |
| Cellular Location | Basolateral cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. |
| Tissue Location | Expressed in the thyroid gland (at protein level). Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one member of a family of sulfate/aniontransporter genes. Family members are well conserved in theirgenomic (number and size of exons) and protein (aa length amongspecies) structures yet have markedly different tissue expressionpatterns. This gene has abundant and specific expression in thekidney. Splice variants that use both alternate transcriptioninitiation and polyadenylation sites have been described for thisgene.
References
Xu, J., et al. J. Am. Soc. Nephrol. 17(4):956-967(2006)Kujala, M., et al. Nephron Exp. Nephrol. 101 (2), E50-E58 (2005) :Barone, S., et al. J. Am. Soc. Nephrol. 15(8):2002-2011(2004)Petrovic, S., et al. Am. J. Physiol. Renal Physiol. 286 (1), F161-F169 (2004) :Petrovic, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (6), G1093-G1103 (2003) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
