EIF2B5 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q13144 |
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Clone Names | 80703069 |
Gene ID | 8893 |
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Other Names | Translation initiation factor eIF-2B subunit epsilon, eIF-2B GDP-GTP exchange factor subunit epsilon, EIF2B5, EIF2BE |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13090a was selected from the N-term region of EIF2B5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EIF2B5 |
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Synonyms | EIF2BE |
Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of five subunits of eukaryotictranslation initiation factor 2B (EIF2B), a GTP exchange factor foreukaryotic initiation factor 2 and an essential regulator forprotein synthesis. Mutations in this gene and the genes encodingother EIF2B subunits have been associated with leukoencephalopathywith vanishing white matter.
References
van der Lei, H.D., et al. Neurology 75(17):1555-1559(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)Glover, E.I., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 (2), R604-R610 (2008) :
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