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PYDC1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WXC3 |
|---|---|
| Clone Names | 100324103 |
| Gene ID | 260434 |
|---|---|
| Other Names | Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13124c was selected from the Center region of PYDC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PYDC1 (HGNC:30261) |
|---|---|
| Function | Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. |
| Cellular Location | Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm |
| Tissue Location | Predominantly expressed in monocytes, macrophages and granulocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
References
Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001)
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